Early Exposure of Fosphenytoin, Levetiracetam and Valproic acid after High Dose Intravenous Administration in Young Children with Benzodiazepine-refractory Status Epilepticus

Fosphenytoin (FOS) and its active form, phenytoin (PHT), levetiracetam (LEV), and valproic acid (VPA) are commonly used second-line treatments of status epilepticus. However, limited information is available regarding LEV and VPA concentrations following high intravenous doses particularly in young...

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Pubblicato in:J Clin Pharmacol
Autori principali: Sathe, Abhishek G., Mishra, Usha, Ivaturi, Vijay, Brundage, Richard, Cloyd, James C., Elm, Jordan J., Chamberlain, James M., Silbergleit, Robert, Kapur, Jaideep, Lowenstein, Daniel H., Shinnar, Shlomo, Cock, Hannah R., Fountain, Nathan B., Babcock, Lynn, Coles, Lisa D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089035/
https://ncbi.nlm.nih.gov/pubmed/33336359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1801
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