Cystathionine‐gamma‐lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy

T cells could be engineered to overcome the aberrant metabolic milieu of solid tumors and tip the balance in favor of a long‐lasting clinical response. Here, we explored the therapeutic potential of stably overexpressing cystathionine‐gamma‐lyase (CTH, CSE, or cystathionase), a pivotal enzyme of the...

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Publicat a:Cancer Sci
Autors principals: Lancien, Melanie, Gueno, Lucile, Salle, Sonia, Merieau, Emmanuel, Beriou, Gaelle, Nguyen, Tuan H., Abidi, Ahmed, Dilek, Nahzli, Solomon, Pierre, Poschmann, Jeremie, Michielin, Olivier, Vuillefroy de Silly, Romain, Vanhove, Bernard, Louvet, Cedric
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088958/
https://ncbi.nlm.nih.gov/pubmed/33609296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14862
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