Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease

Renal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profibrogenic phenotypes, and resort to maladaptive plasticity that ultimately results in renal f...

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Publicat a:Cell Death Dis
Autors principals: Chen, Bohan, Wang, Pei, Liang, Xianhui, Jiang, Chunming, Ge, Yan, Dworkin, Lance D., Gong, Rujun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087712/
https://ncbi.nlm.nih.gov/pubmed/33931588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03709-5
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