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Loss of TLR4 in endothelial cells but not Müller cells protects the diabetic retina

Others have previously reported that global loss of toll-like receptor 4 (TLR4) reduced retinal inflammation. To determine cell specific actions of TLR4 in the retina, we generated diabetic endothelial cell specific and Müller cell specific TLR4 knockout mice. Diabetic Cdh5-Cre TLR4 mice, PDGFRα-Cre...

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Détails bibliographiques
Publié dans:Exp Eye Res
Auteurs principaux: Seidel, Adam, Liu, Li, Jiang, Youde, Steinle, Jena J.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087637/
https://ncbi.nlm.nih.gov/pubmed/33789141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2021.108557
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