Refining pairwise sequence alignments of membrane proteins by the incorporation of anchors

The alignment of primary sequences is a fundamental step in the analysis of protein structure, function, and evolution, and in the generation of homology-based models. Integral membrane proteins pose a significant challenge for such sequence alignment approaches, because their evolutionary relations...

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Bibliographic Details
Published in:PLoS One
Main Authors: Staritzbichler, René, Sarti, Edoardo, Yaklich, Emily, Aleksandrova, Antoniya, Stamm, Marcus, Khafizov, Kamil, Forrest, Lucy R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087094/
https://ncbi.nlm.nih.gov/pubmed/33930031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239881
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