Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis

In human primary dendritic cells (DC) rapamycin—an autophagy inducer and protein synthesis inhibitor—overcomes the autophagy block induced by Mycobacterium tuberculosis (Mtb) and promotes a Th1 response via IL-12 secretion. Here, the immunostimulatory activity of rapamycin in Mtb-infected DC was fur...

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Publicat a:Front Immunol
Autors principals: Etna, Marilena P., Severa, Martina, Licursi, Valerio, Pardini, Manuela, Cruciani, Melania, Rizzo, Fabiana, Giacomini, Elena, Macchia, Gianfranco, Palumbo, Orazio, Stallone, Raffaella, Carella, Massimo, Livingstone, Mark, Negri, Rodolfo, Pellegrini, Sandra, Coccia, Eliana M.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086600/
https://ncbi.nlm.nih.gov/pubmed/33936070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.649475
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