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A novel peptide antagonist of the human growth hormone receptor

Excess circulating human growth hormone (hGH) in vivo is linked to metabolic and growth disorders such as cancer, diabetes, and acromegaly. Consequently, there is considerable interest in developing antagonists of hGH action. Here, we present the design, synthesis, and characterization of a 16-resid...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Basu, Reetobrata, Nahar, Khairun, Kulkarni, Prateek, Kerekes, Olivia, Sattler, Maya, Hall, Zachary, Neggers, Sebastian, Holub, Justin M., Kopchick, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086144/
https://ncbi.nlm.nih.gov/pubmed/33774052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100588
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