Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway

Clear cell renal cell carcinoma (ccRCC) is characterized by abnormal lipid accumulation. Celastrol is a pentacyclic triterpene extracted from Tripterygium wilfordii Hook F with anti-cancer activity. In the present study, the anticancer effects of celastrol on ccRCC and the underlying mechanisms were...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Zhang, Chan-Juan, Zhu, Neng, Wang, Yu-Xiang, Liu, Le-Ping, Zhao, Tan-Jun, Wu, Hong-Tao, Liao, Duan-Fang, Qin, Li
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085775/
https://ncbi.nlm.nih.gov/pubmed/33935779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.658092
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