Mechanism of mutant calreticulin-mediated activation of the thrombopoietin receptor in cancers

Myeloproliferative neoplasms (MPNs) are frequently driven by mutations within the C-terminal domain (C-domain) of calreticulin (CRT). CRT(Del52) and CRT(Ins5) are recurrent mutations. Oncogenic transformation requires both mutated CRT and the thrombopoietin receptor (Mpl), but the molecular mechanis...

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Udgivet i:J Cell Biol
Main Authors: Venkatesan, Arunkumar, Geng, Jie, Kandarpa, Malathi, Wijeyesakere, Sanjeeva Joseph, Bhide, Ashwini, Talpaz, Moshe, Pogozheva, Irina D., Raghavan, Malini
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085772/
https://ncbi.nlm.nih.gov/pubmed/33909030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202009179
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