N-Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and inflammatory pain in mice

Chronic pain is a significant public health problem that afflicts nearly 30% of the global population, but current pharmacotherapies are insufficient. Previous report indicated that N-demethylsinomenine, an active metabolite of sinomenine, is efficacious against postoperative pain. The present study...

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Udgivet i:Sci Rep
Main Authors: Zhou, Zhiyong, Qiu, Nanqing, Ou, Yuntao, Wei, Qianqian, Tang, Wenting, Zheng, Mingcong, Xing, Yaluan, Li, Jie-Jia, Ling, Yong, Li, Junxu, Zhu, Qing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085237/
https://ncbi.nlm.nih.gov/pubmed/33927244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88521-z
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