NLRP3 inflammasome and Bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice

The nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) inflammasome is a critical inflammatory mechanism identified in platelets, which controls platelet activation and aggregation. We have recently shown that the platelet NLRP3 inflammasome is upregulated in sickle cell dise...

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Vydáno v:Biochem Biophys Res Commun
Hlavní autoři: Vogel, Sebastian, Kamimura, Sayuri, Arora, Taruna, Smith, Meghann L., Almeida, Luis E. F., Combs, Christian A., Thein, Swee Lay, Quezado, Zenaide M. N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085042/
https://ncbi.nlm.nih.gov/pubmed/33831782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2021.03.115
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