Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats

BACKGROUND: Recent clinical studies have shown that treatment with LCZ696, a complex containing the angiotensin receptor blocker valsartan and neprilysin inhibitor sacubitril, improves the prognosis of heart failure patients with a reduced ejection fraction. This study evaluated whether LCZ696 affec...

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Detalhes bibliográficos
Publicado no:Cardiol J
Main Authors: Miyoshi, Toru, Nakamura, Kazufumi, Miura, Daiji, Yoshida, Masashi, Saito, Yukihiro, Akagi, Satoshi, Ohno, Yuko, Kondo, Megumi, Ito, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Via Medica 2019
Assuntos:
Basic Science and Experimental Cardiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084392/
https://ncbi.nlm.nih.gov/pubmed/29718530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5603/CJ.a2018.0048
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