Melatonin Alleviates the Suppressive Effect of Hypoxanthine on Oocyte Nuclear Maturation and Restores Meiosis via the Melatonin Receptor 1 (MT1)-Mediated Pathway

It is well known that hypoxanthine (HX) inhibits nuclear maturation of oocytes by elevating the intracellular cAMP level, while melatonin (MT) is a molecule that reduces cAMP production, which may physiologically antagonize this inhibition and restore the meiosis process. We conducted in vitro and i...

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Udgivet i:Front Cell Dev Biol
Main Authors: Wang, Jing, Zhuo, Zhiyong, Ma, Xiao, Liu, Yunjie, Xu, Jing, He, Changjiu, Fu, Yao, Wang, Feng, Ji, Pengyun, Zhang, Lu, Liu, Guoshi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8083900/
https://ncbi.nlm.nih.gov/pubmed/33937242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.648148
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