In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19

BACKGROUND: Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. SARS-CoV-2 nsp12, its RNA polymerase, shares homology in the nucleotide uptake channel with the HCV orthologue enzyme N...

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Bibliografiske detaljer
Udgivet i:J Antimicrob Chemother
Main Authors: Sacramento, Carolina Q, Fintelman-Rodrigues, Natalia, Temerozo, Jairo R, Da Silva, Aline de Paula Dias, Dias, Suelen da Silva Gomes, da Silva, Carine dos Santos, Ferreira, André C, Mattos, Mayara, Pão, Camila R R, de Freitas, Caroline S, Soares, Vinicius Cardoso, Hoelz, Lucas Villas Bôas, Fernandes, Tácio Vinício Amorim, Branco, Frederico Silva Castelo, Bastos, Mônica Macedo, Boechat, Núbia, Saraiva, Felipe B, Ferreira, Marcelo Alves, Jockusch, Steffen, Wang, Xuanting, Tao, Chuanjuan, Chien, Minchen, Xie, Wei, Patel, Dinshaw, Garzia, Aitor, Tuschl, Thomas, Russo, James J, Rajoli, Rajith K R, Pedrosa, Carolina S G, Vitória, Gabriela, Souza, Letícia R Q, Goto-Silva, Livia, Guimarães, Marilia Zaluar, Rehen, Stevens K, Owen, Andrew, Bozza, Fernando A, Bou-Habib, Dumith Chequer, Ju, Jingyue, Bozza, Patrícia T, Souza, Thiago Moreno L
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8083231/
https://ncbi.nlm.nih.gov/pubmed/33880524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkab072
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