Chemical inhibitors of the conserved bacterial transcriptional regulator DksA1 suppressed quorum sensing-mediated virulence of Pseudomonas aeruginosa

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen whose virulence is dependent on quorum sensing (QS). DksA1, an RNA polymerase-binding transcriptional regulator, plays a role in determining a number of phenotypes, including QS-mediated virulence. We therefore envisioned that DksA1 in...

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Udgivet i:J Biol Chem
Main Authors: Min, Kyung Bae, Hwang, Wontae, Lee, Kang-Mu, Kim, June Beom, Yoon, Sang Sun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081920/
https://ncbi.nlm.nih.gov/pubmed/33757766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100576
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