Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3–NANOG Axis

Immunoediting caused by antitumor immunity drives tumor cells to acquire refractory phenotypes. We demonstrated previously that tumor antigen–specific T cells edit these cells such that they become resistant to CTL killing and enrich NANOG(high) cancer stem cell-like cells. In this study, we show th...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Oh, Se Jin, Cho, Hanbyoul, Kim, Suhyun, Noh, Kyung Hee, Song, Kwon-Ho, Lee, Hyo-Jung, Woo, Seon Rang, Kim, Suyeon, Choi, Chel Hun, Chung, Joon-Yong, Hewitt, Stephen M., Kim, Jae-Hoon, Baek, Seungki, Lee, Kyung-Mi, Yee, Cassian, Park, Hae-Chul, Kim, Tae Woo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081060/
https://ncbi.nlm.nih.gov/pubmed/29437706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2325
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