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miRNA activity inferred from single cell mRNA expression

High throughput single-cell RNA sequencing (scRNAseq) can provide mRNA expression profiles for thousands of cells. However, miRNAs cannot currently be studied at the same scale. By exploiting that miRNAs bind well-defined sequence motifs and typically down-regulate target genes, we show that motif e...

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Publicat a:Sci Rep
Autors principals: Nielsen, Morten Muhlig, Pedersen, Jakob Skou
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080788/
https://ncbi.nlm.nih.gov/pubmed/33911110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88480-5
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