Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants

Genome-wide association studies (GWASs) are instrumental in identifying loci harboring common single-nucleotide variants (SNVs) that affect human traits and diseases. GWAS hits emerge in clusters, but the focus is often on the most significant hit in each trait- or disease-associated locus. The rema...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Pinsach-Abuin, Mel·lina, del Olmo, Bernat, Pérez-Agustin, Adrian, Mates, Jesus, Allegue, Catarina, Iglesias, Anna, Ma, Qi, Merkurjev, Daria, Konovalov, Sergiy, Zhang, Jing, Sheikh, Farah, Telenti, Amalio, Brugada, Josep, Brugada, Ramon, Gymrek, Melissa, di Iulio, Julia, Garcia-Bassets, Ivan, Pagans, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080235/
https://ncbi.nlm.nih.gov/pubmed/33948580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100250
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