ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma

BACKGROUND: Therapeutic intervention in metastatic medulloblastoma is dependent on elucidating the underlying metastatic mechanism. We investigated whether an epithelial–mesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasis. METHODS: A 3D Basement Membrane Extract (3D-BME)...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Nasir, Aishah, Cardall, Alice, Othman, Ramadhan T, Nicolaou, Niovi, Lourdusamy, Anbarasu, Linke, Franziska, Onion, David, Ryzhova, Marina, Cameron, Hanna, Valente, Cara, Ritchie, Alison, Korshunov, Andrey, Pfister, Stefan M, Grabowska, Anna M, Kerr, Ian D, Coyle, Beth
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080134/
https://ncbi.nlm.nih.gov/pubmed/33948561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab030
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