Peripheral TIGIT+ T Follicular Helper Cells That Produce High Levels of Interleukin-21 via OX40 Represent Disease Activity in IgG4-Related Disease

OBJECTIVES: Multiple studies suggest that interleukin (IL)-21 plays a pivotal role in the differentiation of B cells and activation of cytotoxic T cells and is involved in the pathogenesis of IgG4-related disease (IgG4-RD). T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) is a new m...

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Vydáno v:Front Immunol
Hlavní autoři: Akiyama, Mitsuhiro, Suzuki, Katsuya, Yoshimoto, Keiko, Yasuoka, Hidekata, Kaneko, Yuko, Takeuchi, Tsutomu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079782/
https://ncbi.nlm.nih.gov/pubmed/33936071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.651357
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