Phase 1 trial of ADI-PEG20 plus cisplatin in patients with pretreated metastatic melanoma or other advanced solid malignancies

BACKGROUND: Arginine depletion interferes with pyrimidine metabolism and DNA damage-repair pathways, and pairing arginine deiminase pegylated with 20,000-molecular-weight polyethylene glycol (ADI-PEG20) with platinum enhances cytotoxicity in vitro and in vivo in arginine auxotrophs. METHODS: This si...

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Publicat a:Br J Cancer
Autors principals: Yao, Shuyang, Janku, Filip, Subbiah, Vivek, Stewart, John, Patel, Sapna Pradyuman, Kaseb, Ahmed, Westin, Shannon Neville, Naing, Aung, Tsimberidou, Apostolia Maria, Hong, David, Piha-Paul, Sarina Anne, Shi, Nai, Johnston, Amanda, Bomalaski, John, Fu, Siqing
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8076217/
https://ncbi.nlm.nih.gov/pubmed/33674736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-01230-8
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