Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention. In this work, we describe the developm...

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Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Shan, Hengyue, Liu, Jianping, Shen, Jiali, Dai, Jialin, Xu, Gang, Lu, Kuankuan, Han, Chao, Wang, Yaru, Xu, Xiaolong, Tong, Yilun, Xiang, Huaijiang, Ai, Zhiyuan, Zhuang, Guanglei, Hu, Junhao, Zhang, Zheng, Li, Ying, Pan, Lifeng, Tan, Li
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Ltd. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8075810/
https://ncbi.nlm.nih.gov/pubmed/33979649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.04.020
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