Naïve CD4+ T Cell Lymphopenia and Apoptosis in Chronic Hepatitis C Virus Infection Is Driven by the CD31+ Subset and Is Partially Normalized in Direct-Acting Antiviral Treated Persons

BACKGROUND: The mechanisms underlying naïve CD4+ lymphopenia during chronic Hepatitis C Virus (HCV) infection are unclear. Whether direct-acting antiviral (DAA) therapy restores peripheral naïve CD4+ T cell numbers and function is unknown. METHODS: We enumerated frequencies and counts of peripheral...

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Publicat a:Front Immunol
Autors principals: Auma, Ann W.N., Shive, Carey L., Lange, Alyssa, Damjanovska, Sofi, Kowal, Corinne, Zebrowski, Elizabeth, Pandiyan, Pushpa, Wilson, Brigid, Kalayjian, Robert C., Canaday, David H., Anthony, Donald D.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8075159/
https://ncbi.nlm.nih.gov/pubmed/33912168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.641230
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