Trained immunity-promoting nanobiologic therapy suppresses tumor growth and potentiates checkpoint inhibition

Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose we developed a bone marrow-avid nanobiologic platform designed specifical...

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Pubblicato in:Cell
Autori principali: Priem, Bram, van Leent, Mandy M.T., Teunissen, Abraham J.P., Sofias, Alexandros Marios, Mourits, Vera P., Willemsen, Lisa, Klein, Emma D., Oosterwijk, Roderick S., Meerwaldt, Anu E., Munitz, Jazz, Prévot, Geoffrey, Verschuur, Anna Vera, Nauta, Sheqouia A., van Leeuwen, Esther M., Fisher, Elizabeth L., de Jong, Karen A.M., Zhao, Yiming, Toner, Yohana C., Soultanidis, Georgios, Calcagno, Claudia, Bomans, Paul H.H., Friedrich, Heiner, Sommerdijk, Nico A.J.M., Reiner, Thomas, Duivenvoorden, Raphaël, Zupančič, Eva, Di Martino, Julie S., Kluza, Ewelina, Rashidian, Mohammad, Ploegh, Hidde L., Dijkhuizen, Rick M., Hak, Sjoerd, Pérez-Medina, Carlos, Bravo-Cordero, Jose Javier, de Winther, Menno P.J., Joosten, Leo A.B., van Elsas, Andrea, Fayad, Zahi A., Rialdi, Alexander, Torre, Denis, Guccione, Ernesto, Ochando, Jordi, Netea, Mihai G., Griffioen, Arjan W., Mulder, Willem J.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8074872/
https://ncbi.nlm.nih.gov/pubmed/33125893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.09.059
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