Differences in PARP Inhibitors for the Treatment of Ovarian Cancer: Mechanisms of Action, Pharmacology, Safety, and Efficacy

Poly(ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for PARP cofactor (NAD+) and trapping PARP on the DNA. In this way, they inhibit single-strand DNA damage repair. These dr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Valabrega, Giorgio, Scotto, Giulia, Tuninetti, Valentina, Pani, Arianna, Scaglione, Francesco
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073512/
https://ncbi.nlm.nih.gov/pubmed/33921561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22084203
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