Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro

Effective therapeutics are urgently needed to counter infection and improve outcomes for patients suffering from COVID-19 and to combat this pandemic. Manipulation of epigenetic machinery to influence viral infectivity of host cells is a relatively unexplored area. The bromodomain and extraterminal...

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Pubblicato in:Biomedicines
Autori principali: Gilham, Dean, Smith, Audrey L., Fu, Li, Moore, Dalia Y., Muralidharan, Abenaya, Reid, St. Patrick M., Stotz, Stephanie C., Johansson, Jan O., Sweeney, Michael, Wong, Norman C. W., Kulikowski, Ewelina, El-Gamal, Dalia
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072876/
https://ncbi.nlm.nih.gov/pubmed/33919584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9040437
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