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Selection for cooperativity causes epistasis predominately between native contacts and enables epistasis-based structure reconstruction
Epistasis and cooperativity of folding both result from networks of energetic interactions in proteins. Epistasis results from energetic interactions among mutants, whereas cooperativity results from energetic interactions during folding that reduce the presence of intermediate states. The two conce...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8072402/ https://ncbi.nlm.nih.gov/pubmed/33879570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010057118 |
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