The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results in cardiac contractile dysfunction in cultured H9C2 ca...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Wüst, Rob C. I., Coolen, Bram F., Held, Ntsiki M., Daal, Mariah R. R., Alizadeh Tazehkandi, Vida, Baks-te Bulte, Luciënne, Wiersma, Marit, Kuster, Diederik W. D., Brundel, Bianca J. J. M., van Weeghel, Michel, Strijkers, Gustav J., Houtkooper, Riekelt H.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8071362/
https://ncbi.nlm.nih.gov/pubmed/33921053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22084100
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