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Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors

Natural products based on imidazole scaffolds have inspired the discovery of a wide variety of bioactive compounds. Herein, a series of imidazoles that act as competitive and potent cruzain inhibitors was investigated using a combination of ligand- and structure-based drug design strategies. Quantit...

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Bibliografiske detaljer
Udgivet i:Biomolecules
Main Authors: Medeiros, Alex R., Ferreira, Leonardo L. G., de Souza, Mariana L., de Oliveira Rezende Junior, Celso, Espinoza-Chávez, Rocío Marisol, Dias, Luiz Carlos, Andricopulo, Adriano D.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8071344/
https://ncbi.nlm.nih.gov/pubmed/33920961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040579
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