Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

SIMPLE SUMMARY: In patients with advanced cancer, hypoxic stress shapes NK cells toward tumor-resistant and immunosuppressive phenotypes. Therefore, a strategy to restore NK cell function within hypoxia would be crucial for successful tumor immunotherapy. By manipulating pO(2) exposure to naïve vs....

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Vydáno v:Cancers (Basel)
Hlavní autoři: Lim, Seon Ah, Moon, Yunwon, Shin, Min Hwa, Kim, Tae-Jin, Chae, Sehyun, Yee, Cassian, Hwang, Daehee, Park, Hyunsung, Lee, Kyung-Mi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8071270/
https://ncbi.nlm.nih.gov/pubmed/33920906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081904
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