Integrating neuroimaging biomarkers into the multicentre, high-dose erythropoietin for asphyxia and encephalopathy (HEAL) trial: rationale, protocol and harmonisation

INTRODUCTION: MRI and MR spectroscopy (MRS) provide early biomarkers of brain injury and treatment response in neonates with hypoxic-ischaemic encephalopathy). Still, there are challenges to incorporating neuroimaging biomarkers into multisite randomised controlled trials. In this paper, we provide...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Wisnowski, Jessica L, Bluml, Stefan, Panigrahy, Ashok, Mathur, Amit M, Berman, Jeffrey, Chen, Ping-Sun Keven, Dix, James, Flynn, Trevor, Fricke, Stanley, Friedman, Seth D, Head, Hayden W, Ho, Chang Y, Kline-Fath, Beth, Oveson, Michael, Patterson, Richard, Pruthi, Sumit, Rollins, Nancy, Ramos, Yanerys M, Rampton, John, Rusin, Jerome, Shaw, Dennis W, Smith, Mark, Tkach, Jean, Vasanawala, Shreyas, Vossough, Arastoo, Whitehead, Matthew T, Xu, Duan, Yeom, Kristen, Comstock, Bryan, Heagerty, Patrick J, Juul, Sandra E, Wu, Yvonne W, McKinstry, Robert C
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Paediatrics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070884/
https://ncbi.nlm.nih.gov/pubmed/33888528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2020-043852
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