Evofosfamide Is Effective against Pediatric Aggressive Glioma Cell Lines in Hypoxic Conditions and Potentiates the Effect of Cytotoxic Chemotherapy and Ionizing Radiations

SIMPLE SUMMARY: Despite many therapeutic approaches attempted over the last years, the prognosis of children with high-grade glioma or diffuse intrinsic pontine glioma remains dismal. Hypoxia-activated prodrugs (HAPs) were developed to target hypoxic areas within solid tumors as gliomas. Evofosfamid...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Bailleul, Quentin, Navarin, Pauline, Arcicasa, Mélanie, Bal-Mahieu, Christine, Carcaboso, Angel Montero, Le Bourhis, Xuefen, Furlan, Alessandro, Meignan, Samuel, Leblond, Pierre
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070185/
https://ncbi.nlm.nih.gov/pubmed/33918823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081804
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