Octreotide and Pasireotide Combination Treatment in Somatotroph Tumor Cells: Predominant Role of SST(2) in Mediating Ligand Effects

SIMPLE SUMMARY: First-generation somatostatin receptor ligands, such as octreotide, are the first-line medical therapy in acromegaly. Octreotide shows preferential binding for somatostatin receptor subtype 2 (SST(2)), while the second-generation ligand, pasireotide, has high affinity for multiple SS...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Amarù, Jessica, Barbieri, Federica, Arvigo, Marica, Solari, Agnese, Bajetto, Adriana, Nista, Federica, Campana, Claudia, Gaggero, Gabriele, Prior, Alessandro, Criminelli Rossi, Diego, Zona, Gianluigi, Ferone, Diego, Florio, Tullio, Gatto, Federico
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8069349/
https://ncbi.nlm.nih.gov/pubmed/33920241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081816
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