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The C-Terminal Domain of Nef(mut) Is Dispensable for the CD8(+) T Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles
Intramuscular injection of DNA vectors expressing the extracellular vesicle (EV)-anchoring protein Nef(mut) fused at its C-terminus to viral and tumor antigens elicit a potent, effective, and anti-tolerogenic CD8(+) T cell immunity against the heterologous antigen. The immune response is induced thr...
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| Publicat a: | Vaccines (Basel) |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8068889/ https://ncbi.nlm.nih.gov/pubmed/33921215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines9040373 |
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