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Novel Benzenesulfonate Scaffolds with a High Anticancer Activity and G2/M Cell Cycle Arrest

SIMPLE SUMMARY: Sulfonate derivatives have limited application in pharmacology. Only few examples of small-molecule alkylating agents used as DNA poisons are known. This is the first report presenting strong anticancer activity of aromatic sulfonates based on quinazolines. The screening revealed tha...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Malarz, Katarzyna, Mularski, Jacek, Kuczak, Michał, Mrozek-Wilczkiewicz, Anna, Musiol, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068801/
https://ncbi.nlm.nih.gov/pubmed/33918637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081790
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