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Simvastatin treatment varies the radiation response of human breast cells in 2D or 3D culture

Background Statins inhibit the cholesterol biosynthesis and are used as cholesterol-lowering agents in fat-metabolism disorders. Furthermore, several studies state that statins have supportive functions in breast cancer treatment. Therefore, simvastatin (SVA) as a potential radiosensitizer should be...

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Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Manda, Katrin, Juerß, Dajana, Fischer, Paul, Schröder, Annemarie, Koenen, Annelie, Hildebrandt, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068713/
https://ncbi.nlm.nih.gov/pubmed/33313978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-020-01046-6
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