Presynaptic store-operated Ca(2+) entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

Store operated calcium entry (SOCE) is activated by depletion of Ca(2+) from the endoplasmic reticulum (ER) and mediated by stromal interaction molecule (STIM) proteins. Here, we show that in rat and mouse hippocampal neurons acute ER Ca(2+) depletion increases presynaptic Ca(2+) levels and glutamat...

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Udgivet i:Neuron
Main Authors: Chanaday, Natali L., Nosyreva, Elena, Shin, Ok-Ho, Zhang, Hua, Aklan, Iltan, Atasoy, Deniz, Bezprozvanny, Ilya, Kavalali, Ege T.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068669/
https://ncbi.nlm.nih.gov/pubmed/33711258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2021.02.023
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