Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma

Background Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly malignant brain tumor with limited treatment options and short survival times. We identified novel BRAF (47-438del) and PIK3R1 (G376R) mutations in a gli...

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Vydáno v:Invest New Drugs
Hlavní autoři: Saeed, Mohamed E. M., Kadioglu, Onat, Greten, Henry Johannes, Yildirim, Adem, Mayr, Katharina, Wenz, Frederik, Giordano, Frank A., Efferth, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2020
Témata:
Preclinical Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068653/
https://ncbi.nlm.nih.gov/pubmed/33313992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-020-01037-7
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