Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation

Aggregates of TAR DNA-binding protein (TDP-43) are a hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although TDP-43 aggregates are an undisputed pathological species at the end stage of these diseases, the molecular changes underlying the initiation o...

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Pubblicato in:Biomolecules
Autori principali: Pakravan, Donya, Michiels, Emiel, Bratek-Skicki, Anna, De Decker, Mathias, Van Lindt, Joris, Alsteens, David, Derclaye, Sylvie, Van Damme, Philip, Schymkowitz, Joost, Rousseau, Frederic, Tompa, Peter, Van Den Bosch, Ludo
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068378/
https://ncbi.nlm.nih.gov/pubmed/33917983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040548
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