Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment

Genetic alterations, especially the K-Ras mutation, carry the heaviest burden in the progression of pancreatic precursor lesions into pancreatic ductal adenocarcinoma (PDAC). The tumor microenvironment is one of the challenges that hinder the therapeutic approaches from functioning sufficiently and...

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Detalhes bibliográficos
Publicado no:Biomedicines
Main Authors: Javadrashid, Darya, Baghbanzadeh, Amir, Derakhshani, Afshin, Leone, Patrizia, Silvestris, Nicola, Racanelli, Vito, Solimando, Antonio Giovanni, Baradaran, Behzad
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067185/
https://ncbi.nlm.nih.gov/pubmed/33918146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9040373
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