Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASH

Dysregulation of glucose homeostasis plays a major role in the pathogenesis of non-alcoholic steatohepatitis (NASH) as it activates proinflammatory and profibrotic processes. Beneficial effects of antiglycemic treatments such as GLP-1 agonist or SGLT-2 inhibitor on NASH in patients with diabetes hav...

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Vydáno v:Biomedicines
Hlavní autoři: Hupa-Breier, Katharina Luise, Dywicki, Janine, Hartleben, Björn, Wellhöner, Freya, Heidrich, Benjamin, Taubert, Richard, Mederacke, Young-Seon Elisabeth, Lieber, Maren, Iordanidis, Konstantinos, Manns, Michael P., Wedemeyer, Heiner, Hardtke-Wolenski, Matthias, Jaeckel, Elmar
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8066839/
https://ncbi.nlm.nih.gov/pubmed/33808404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9040353
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