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High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism

Diabetes promotes an angiostatic phenotype in the microvascular endothelium of skeletal muscle and skin. Angiogenesis-related microRNAs (angiomiRs) regulate angiogenesis through the translational repression of pro- and anti-angiogenic genes. The maturation of micro-RNA (miRs), including angiomiRs, r...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Lam, Brian, Nwadozi, Emmanuel, Haas, Tara L., Birot, Olivier, Roudier, Emilie
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065922/
https://ncbi.nlm.nih.gov/pubmed/33801773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10040742
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