Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia

Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin synthesis, resulting in excess toxic free heme in erythroid progenitors, early differentiation arrest, and pure red cell aplasia. In this study, D...

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Publicado en:Cells
Main Authors: Qanash, Husam, Li, Yongqin, Smith, Richard H., Linask, Kaari, Young-Baird, Sara, Hakami, Waleed, Keyvanfar, Keyvan, Choy, John S., Zou, Jizhong, Larochelle, Andre
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065708/
https://ncbi.nlm.nih.gov/pubmed/33810313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10040734
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