SPECT Imaging of SST2-Expressing Tumors with (99m)Tc-Based Somatostatin Receptor Antagonists: The Role of Tetraamine, HYNIC, and Spacers

[(99m)Tc]Tc-HYNIC-TOC is the most widely used (99m)Tc-labeled somatostatin receptor (SST) agonist for the SPECT imaging of SST-expressing tumors, such as neuroendocrine tumors. Recently, radiolabeled SST antagonists have shown improved diagnostic efficacy over agonists. (99m)Tc-labeled SST antagonis...

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Vydáno v:Pharmaceuticals (Basel)
Hlavní autoři: Gaonkar, Raghuvir Haridas, Wiesmann, Fabius, Del Pozzo, Luigi, McDougall, Lisa, Zanger, Sandra, Mikołajczak, Renata, Mansi, Rosalba, Fani, Melpomeni
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065591/
https://ncbi.nlm.nih.gov/pubmed/33800582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14040300
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