COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings of frequent pulmonary thromboembolism (17%), high pu...

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Pubblicato in:Nat Commun
Autori principali: Rysz, Susanne, Al-Saadi, Jonathan, Sjöström, Anna, Farm, Maria, Campoccia Jalde, Francesca, Plattén, Michael, Eriksson, Helen, Klein, Margareta, Vargas-Paris, Roberto, Nyrén, Sven, Abdula, Goran, Ouellette, Russell, Granberg, Tobias, Jonsson Fagerlund, Malin, Lundberg, Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065208/
https://ncbi.nlm.nih.gov/pubmed/33893295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22713-z
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