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VEHiCLE: a Variationally Encoded Hi-C Loss Enhancement algorithm for improving and generating Hi-C data

Chromatin conformation plays an important role in a variety of genomic processes. Hi-C is one of the most popular assays for inspecting chromatin conformation. However, the utility of Hi-C contact maps is bottlenecked by resolution. Here we present VEHiCLE, a deep learning algorithm for resolution e...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Highsmith, Max, Cheng, Jianlin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065109/
https://ncbi.nlm.nih.gov/pubmed/33893353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88115-9
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