Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase

AIMS: Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque haemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and activating transcription factor 1 (ATF1). The antidiabetic drug metformin may also activate AMPK-depend...

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Publicat a:Cardiovasc Res
Autors principals: Seneviratne, Anusha, Cave, Luke, Hyde, Gareth, Moestrup, Soren Kragh, Carling, David, Mason, Justin C, Haskard, Dorian O, Boyle, Joseph James
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064441/
https://ncbi.nlm.nih.gov/pubmed/32667970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvaa171
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