Exosomes derived from microRNA-512-5p-transfected bone mesenchymal stem cells inhibit glioblastoma progression by targeting JAG1

In this study, we demonstrate that bone mesenchymal stem cell (BMSC)-derived exosomes alter tumor phenotypes by delivering miR-512-5p. miR-512-5p was downregulated in glioblastoma tissues and cells, and Jagged 1 (JAG1) was the target gene of miR-512-5p. We clarified the expression patterns of miR-51...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Yan, Tengfeng, Wu, Miaojing, Lv, Shigang, Hu, Qing, Xu, Wenhua, Zeng, Ailiang, Huang, Kai, Zhu, Xingen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064202/
https://ncbi.nlm.nih.gov/pubmed/33795521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202747
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