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Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis
• AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA. • MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity. • Dysregulated complement system primes neutrophils. • MPO-ANCA directly activates neutrophils to induce NETosis followed by releasing NETs....
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| Publicado en: | J Transl Autoimmun |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8063861/ https://ncbi.nlm.nih.gov/pubmed/33912820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtauto.2021.100094 |
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