Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy is typically restricted to cytotoxic chemotherapy, which fails more often in patients with elevated circulating cholesterol. Liver x receptors are ligand-depen...

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Vydáno v:Oncogene
Hlavní autoři: Hutchinson, Samantha A., Websdale, Alex, Cioccoloni, Giorgia, Røberg-Larsen, Hanne, Lianto, Priscilia, Kim, Baek, Rose, Ailsa, Soteriou, Chrysa, Pramanik, Arindam, Wastall, Laura M., Williams, Bethany J., Henn, Madeline A., Chen, Joy J., Ma, Liqian, Moore, J. Bernadette, Nelson, Erik, Hughes, Thomas A., Thorne, James L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062267/
https://ncbi.nlm.nih.gov/pubmed/33742124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01720-w
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